Evaluation of Antinociceptive Effect of Paracetamol, Ketorolac and Tramadolhydrochloride in Arthritic Rat by Pain Induced Functional Impairment Model
Kusum Kumari1, Manju Gari1 , Priyanki2* and Pramveer Kumar11Department of Pharmacology and Therapeutics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, 834009
2MGM Medical College , Jamshedpur, India
Corresponding Author E-mail : priyanki.mishra@gmail.com
Abstract: Pain is a major burden on limited health care resources for all the nations. In the research model called “pain-induced functional impairment in the rat” (PIFIR model), both nociception and antinociception happen similar to that experienced in arthritic -type pain situations. This experiment can be used to determine efficacy, potency and the duration of antinociceptive effect caused by a drug that is either administered alone or in combination with some other drug. In this study, the drugs that have been used are Ketorolac, paracetamol and Tramadolfor evaluating and comparing their efficacy. Healthy male albino rats have been used for the study. Pain was induced with an intra articular injection of uric acid (32% ) in the right side knee joint of the animal. Electrodes were attached to each of the hind paw between the plantar pads. The animal was then placed on an aluminium cylinder . The cylinder was rotated which forced the rat to walk. The time of contact between each of the hind paw with the rotating cylinder was recorded. When the conducting pad placed under the animal’s paw contacted the cylinder floor, a circuit was closed and the time for which the circuit conducted electricity was recorded. 2.5 hrs. after uric acid injection , analgesic agents under study were administered. This time was recorded as time zero (t0) for measurement of effects of the analgesic drugs. After the Drugs were adminstered at time zero, the rats were made to walk on rotating cylinder for 2 minutes every one hour for next 4 houts and the time of contact of both the paws was measured. The ratio of time of contact of both the legs was expressed in terms of Functional Index (FI) and the time required to reach this response (t) was recorded .The maximum efficacy is seen with Tramadolfollowed by paracetamol closely followed by Ketorolac. Paracetamol has a fast onset while Tramadolis slower in onset.
Keywords: PIFIR; Antinociceptive Effect; Ketorolac; Paracetamol; Tramadol Back to TOC