Ameliorative Effect of Terminalia Chebula on Hematological Complications Induced by Doxorubicin

Aamina M¹, Ahmad Alhowail², Maha Aldubayan², Rabbani SI^1,2*

¹Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.

²Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah,  Kingdom of Saudi Arabia.

Corresponding Author E-mail : syedrabbani09@yahoo.com

Abstract: The effect of ethanolic extract of Terminalia chebula was tested on hematological complications induced by doxorubicin (DXR) in male and female rats. Hematological parameters were evaluated by estimating the hemoglobin content and total leucocytes count. The antioxidant assay was done by finding the serum catalase level. The results of the study was analyzed by Two-way Anova and Bonferroni tests and p<0.05 was considered to indicate the significance of the results. Our data indicated DXR at 2.5 mg/kg significantly (p<0.001) decreased the hemoglobin content, total WBC count and serum catalase level compared to control groups in both male and female rats. Administration of Terminalia chebula extract at 0.5 and 1 g/kg significantly (p<0.05) improved the level of hemoglobin content and total WBC count and elevated the catalase concentration compared to DXR.  The results suggest that co-administration of Terminalia chebula can prevent the hematological complications of doxorubicin possibly by elevating the antioxidant status.

Keywords: Terminalia chebula; Doxorubicin; Hematological Complications; Oxidative Stress

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