Adiponectin Level Association with MDA in the Patients with Type 2 Diabetes Mellitus
Rachna Sharma1*, P. Satyanarayana1, Pallavi Anand1 and Ganpati Aruna Kumari21Department of Biochemistry, Rama Medical College, Hospital and Research Centre, Kanpur
2Department of Pedodontics and Peventive Dentistry, Malla Reddy Dental College for Women, Suraram, Hyderabad.
Corresponding Author E-mail : drrachna99@gmail.com
Abstract: MDA level were established to be augmented in poor controlled T2DM and is positively correlated with progression of diabetes while adiponectin is negatively correlated with diabetes progression furthermore adiponectin high level is associated with low risk of cardio-metabolic complication and low risk of macro vascular complication in patient with T2DM. To find out the correlation between Adiponectin and MDA level in patient with T2DM (type 2 Diabetes Mellitus). 120 sample size, age above 30yrs, was taken in present study from sub urban population grouped as T2DM, Prediabetic and healthy non diabetic as control group Mean ±SD (n=120) MDA =3.94±1.02 in Diabetic group, MDA=1.93±0.31 in prediabetic group and control group MDA = 2.80±1.51, While adiponectin level Mean ±SD (n=120) in diabetic group =3.94±1.02, adiponectin in prediabetic group=9.72±0.31 and the control group adiponectin level =10.81±2.24 Our study suggest that MDA level are augmented with progression of Diabetes Mellitus (T2DM) especially poor controlled T2DM ,MDA blood level are high in T2DM and prediabetic group as compared to control group while low level of adiponectin was found in prediabetic patient group and T2DM group indicating risk of diabetic complication as compared to controlled group which have high level of adiponectin . Also the study confirmed Adiponectin is a reliable biochemical indicator and its correlation in diabetic patient, it reduces the risk of diabetes and diabetic complication and metabolic syndrome and insulin resistance.
Keywords: Adiponectin; Lipid Peroxidation; Malondialdehyde (MDA); Oxidative Stress; Pre diabetes; Type 2 Diabetes Mellitus Back to TOC