Effective Dose and Safety Profile of Purple Sweet Potato Tablet Preparation in Rats With High Cholesterol Diet
I Made Jawi1
, I Wayan Putu Sutirta Yasa2, Agung Nova Mahendra1* and I Wayan Sumardika11Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
2Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
Corresponding Author E-mail : novamahendra@unud.ac.id
Abstract: Tablet is a solid preparation which is proven more stable and practical to be stored than the liguid counterpart, therefore the tablet form of purple sweet potato extract (PSPE) is expected to resolve the instability issues of liquid preparation. Single dose of PSPE tablet has been shown to exhibit weaker effect than the liquid preparation. The purpose of this study was to determine the effective dose of PSPE tablet in preventing oxidative stress and improvement of the lipid profile of the hyperlipidemic rats. In this study, we also investigated the safety of the tablet on rat’s livers and kidneys. This study was an experimental laboratoric study, with randomized pre- and post-test control group design. Subjects were assigned into 4 groups (7 rats in each group). Group 1 was control group, which were given high cholesterol diet for 4 weeks. Group 2, 3 and 4 were treatment groups, which were given high cholesterol diet and PSPE tablet of 100 mg/day, 2 x 100 mg/day, and 3 x 100mg/day, respectively, for 4 weeks. We found that the best dose was 2 x 100mg/rat/day in term of lipid profile, oxidative stress, and effect on liver and kidney. In conclusion, the relatively effective dose for hypercholesterolemia and oxidative stress mitigation, and safest dose of PSPE tablet for livers and kidneys of high cholesterol-fed rats is 2 x 100 mg/day.
Keywords: Hypercholesterolemia, Oxidative Stress, Liver and Kidney Function, Purple Sweet Potato Extract Tablet Back to TOC