A Comparative Antidiabetic Activity of the Three Plants Found in Terai and Duars Region of West Bengal, India

Uttam Sharma¹*, Sabyasachi Das², Soumya Deb¹, Ram Kumar Sahu³, Santosh Fattepur⁴

¹Institute of Pharmacy, Jalpaiguri, W.B., India, 735101

²Calcutta Medical College and Hospital, Kolkata, W.B., India, 700073

³Department of Pharmaceutical Science, Assam University, Silchar, Assam, India, 788011

⁴School of Pharmacy, Management and Sciences University, Shah Alam, Selangor Darul Ehsan, Malasia, 40100

Corresponding Author E-mail : shuttam@gmail.com

Abstract: The northernmost piece of West Bengal touching the feet of Eastern Himalaya is by and large alluded as Terai and Duars (West and East of the stream Tista, separately). From this area the leaves of Swietenia macropphylla, Litsea glutinosa Robinson and Phlogacanthus thyrsiformis were selected for antidiabetic activity and till date no scientific evidence available for antidiabetic activity. The Ethyl acetate extracts of these three plants were orally administered to the Streptozotocin induced diabetic rats. These extracts significantly regulate the blood glucose levels in diabetic rats and indicating the antidiabetic activity of these plants. The antidiabetic activity demonstrated by plants were in following order Phlogacanthus thyrsiformis>Swietenia macrophylla>Litsea glutinosa, respectively. In addition, it significantly recovered lipid profile levels and prevented the decrease in body weight as well as serum insulin level.

Keywords: Antidiabetic; Glibenclamide; Medicinal Plant from Terai- Duars; Lipid Profile; Streptozotocin

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