In Silico Vaccine Design against Mycoplasma Hominis Infections
Shilpa Shiragannavar*
and Shivakumar MadagiKarnataka State Akkamahadevi Women’s University, Vijayapura
Corresponding Author E-mail : shilpa.shiragannavar@gmail.comAbstract: Mycoplasma hominis is a gram negative bacteria belonging to class Mollicutes, commonly present in men and women of reproductive age. In women it affects the genital tract and is involved in causing Pelvic Inflammatory Disease, ectopic pregnancy, miscarriage, epididymitis in men and sometimes prolonged infection may lead to infertility. At present there is no effective prophylaxis for M.hominis infections. The current work involves insilico reverse vaccinology approach for identifying the immunogens as vaccine candidates that can be effective against reinfections and should be capable of inducing long-term protective immunity against Mycoplasma infections. The study identifies the putative vaccine candidates that are membrane bound with high antigenicity properties which involves identification of T-cell and B-cell epitopes that induce humoral immunity as well as cell-mediated immunity and makes the body stronger against infections and effective for reinfections. The epitope ‘STNYYNLYF’ showed good binding interactions 9.80Kcal/mol with HLA-C*05:01 and maximum population coverage.
Keywords: Antigenicity; Docking; In-Silico; Mycoplasma Hominis ; Vaccine Back to TOC