Does Administration of Vitamin C Improves Osteoporosis in Post-Menopausal Women- A Single Center Randomized Case Control Study
Bijan Rezakhaniha1, Shamim Fattah Hesari2 and Peyman Karimi Goudarzi31Department of Urology, Imam Reza Hospital, Tehran, Iran.
2Orthopedic Surgeon, Department of Surgery, Imam Reza Hospital, Tehran, Iran.
3Department of Neurosurgery, Imam Reza Hospital, Tehran, Iran.
Abstract: Osteoporosis in elderly is a worldwide problem with high cost on health care systems Prevention of osteoporosis and its associated fractures, improves quality of life, and reduces the financial burden of treatment costs. Standard treatment regimen includes bisphosphonate, calcium, and Vitamin D3. In this paper we have studied the effect of daily administration Vitamin C on osteoporosis improvement. We studied 66osteopenic to osteoporotic (T score <-1) patients referred to IMAM REZA hospitalduring 2012-2014 years . Cases were randomized in two groupsof 33 patients. Both control and trial group were treated for osteoporosis with a regimen composed of alendronate 70mg weekly, 3 calcium carbonate (500mg) tablets per day and parenteral Vitamin D3 injection once a month. Thetrial group also received one Vitamin C tablet (250 mg) per day. Patient were followed for at least 12 month. After one year of treatment bone marrow density (BMD) was evaluated again. There was no statistically significant difference between controls and the trail group at the beginning of the studyregarding demographic (age, weight, and height) and BMD. After one year of treatment the trial group, showed significantly better BMD than the control group(p<0.05). Addition of Vitamin C improves the outcome of osteoporosis.This is as safe and a low cost addition to standard treatment.
Keywords: Osteoporosis; Osteopenia; Vitamin C; Ascorbic acid; Bone mineral densitometry Back to TOC