Synbiotic Purple Sweet Potato Yogurt Ameliorate Lipid Metabolism in High Fat Diet Mice Model

Astrid Feinisa Khairani^1*, Umar Islami², Mas Rizky Anggun Syamsunarno³and Uci Ary Lantika⁴

¹Division of Cell Biology, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

²Graduate School of Biomedical Sciences Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

³Division of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

⁴Department of Histology and Medical Biology, Faculty of Medicine, Universitas Islam Bandung, Bandung, West Java, Indonesia

Corresponding Author E-mail : astrid.khairani@unpad.ac.id

Abstract: Dyslipidemia has high prevalence worldwide. Unhealthy diet such as high calories and high fat contribute to dyslipidemia. Purple sweet potato yogurt is a synbiotic product containing combination of probiotic fermentation and natural ingredient (prebiotic). Probiotics give beneficial effect to intestinal function. Purple sweet potato serves as prebiotic, also contains anthocyanin as antioxidant. This experimental study aimed to identify the effect of purple sweet potato yogurt consumption towards lactic acid bacteria colony in the intestine, lipid profile (total cholesterol, triglyceride, LDL), body weight, visceral fats, and liver weight of male mice model (Balb-c) with high fat diet. Total of 30 male mice were divided into six groups with different treatment on its diet. Lipid profiles were investigated using enzymatic colorimetric assay. Statistical data was analyzed using one-way ANOVA and post hoc tukey multiple comparison test. Result shown that in the group with administration of 0.3 mL of purple sweet potato yogurt had significantly increase the growth of lactic acid bacteria in the intestine (p<0.0001). The same group also shown favorable outcome in total cholesterol, triglyceride, LDL level, visceral fat and liver weight. Purple sweet potato yogurt has potential protective effect in lipid metabolism under high fat diet condition. Thus, further study is needed to explore more detail on its mechanism.

Keywords: Anthocyanin; Dyslipidemia; High Fat Diet; Lipid Profile; Lactic Acid Bacteria; Synbiotic

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