Synthesis and Antimicrobial Activity of some Quinazolinone Derivatives

Ambuj Singh^1*, S. K. Prajapati, K. P. Namdeo², V. K. Singh and S. K. Verma

¹Institute of Pharmacy, Bundelkhand University, Jhansi.

²S. L. T. Institute of Pharmaceutical Sciences, G.G.U., Bilaspur, Chhatisgarh.

Abstract: Synthesis of six 2,3,6-trisubstituted Quinazolin-4-one is reported. All six compounds contain a bromine atom at position 6, phenylimino thiazolidinone group at position 2 and 3 different derivatives has been synthesized by changing X (A-1: benzaldehyde, A-2: m-chlorobenzaldehyde, A-3: o-hydroxybenzaldehyde, A-4: p-methoxybenzaldehyde, A-5: o-nitrobenzaldehyde, A-6: m-nitrobenzaldehyde). All the synthesized compounds work evaluated for their antimicrobial (against two gram positive and two gram negative microorganism) and antifungal activity (against A. niger and C. albicans).

Keywords: Antimicrobial activity; Quinazolinone derivatives

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