Oxidative Stress, Neutrophil Elastase and Vascular Endothelial Growth Factor in Obese Pregnant Women with Preeclampsia
Moushira Zakia1, Taghreed Shalabi2, Tamer Hussein3, Mohamed Hammam4, Eman Youness5* and Hala T. El-Bassyouni6
Corresponding Author Email: hoctober2000@yahoo.com
1Biological Anthropology Department, Medical Research Division, National Research Centre,Egypt
2Prenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Division, National Research Centre, Egypt
3Reproductive Health Research Department, Medical Research Division, National Research Centre, Egypt
4Obstetrics and Gynecology-Cairo University
5Medical Biochemistry Department, Medical Research Division, National Research Centre, Egypt
6Clinical Genetics Department,Human Genetics and Genome Research Division, National Research Centre, Giza, Egypt
Abstract: Oxidative stress, inflammation, and vascular endothelial proliferation and obesity are risk factors associated with preeclampsia (PE). Thepresent study aimed to investigate the levels of malondialdehyde (MDA) as a putative circulatory marker of oxidative stress, neutrophil Elastase (NE) as inflammatory marker andvascular endothelial growth factor (VEGF) as marker for vascular permeability-enhancing activities inobese women withpreeclampsia PE and compare withnormal pregnancy women. The study was carried out on 50 pregnant obese women with PE and 50 normal pregnant women. The preeclampsia women were characterized with high blood pressure 160/110 mmHg and proteinuria. The gestational age ranged from ≥32 weeks to <37 weeks. Pre pregnancyweightwas recorded. Body mass index (BMI) was calculatedat delivery.SerumMDA, NEand VEGF were estimatedby ELISA. Significant higher levels of serum MAD,NE and VEGF were observed in obese PE patients as compared to normal controls. Our results suggested thatobesity;oxidative stress, NEandVEGFbiomarkers are risk factors for PE,emphasizing their role as feasible candidate risk markersfor cases withhigh blood pressure in early pregnancy.
Keywords: Malonaldehyde; Neutrophil Elastase; Preeclampsia; VEGF Back to TOC