A Probe into Prohealing Potential of Glyceryl Trinitrate
Smita A. Surale-Patil1
, Tatyasaheb Patil2 and Ravindra Kulkarni31Department of pharmacology, Krishna Institute of Medical Sciences Deemed To be University, Karad, Maharashtra, India, Pincode- 415110
2Pharmacologist Consultant Physician, Gurukripa, Station Road, Miraj, Maharashtra, India
3Bharati Vidyapeeth Deemed University Medical College and Hospital, Sangli
Corresponding Author E-mail: smitaasp73@gmail.com
Abstract: Wound healing is a complex, delicate process which consists of series of cellular and biochemical events leading to re-establishment of anatomical continuity. Anal fissure is a painful, chronic, non-healing wound. Its chronicity is due to spasm of anal sphincter and local ischemia. It is treated surgically by sphincterotomy to eliminate sphincter spasm. Therefore, Glyceryl trinitrate(GTN) has been used as a non-surgical alternative treatment due to its spasmolytic activity. The present study was undertaken to determine wound healing potential of GTN in wistar rats. 18 male wistar rats were divided in three groups, 6 rats per group Control (Normal saline), GTN, GTN Ointment base. A 500 mm2 excisional wound , circular in shape was created . The drugs were applied topically over the wound, one day after the wounding. Two parameters were studied viz; wound contraction and period of epithelization. Glyceryl trinitrate has shown statistically signfiicant difference in wound contraction compared to control on 10th day. Period of epithelization was not reduced significantly by Glyceryl trinitrate when compared to Control. Glyceryl trinitrate has wound healing potential apart from its spasmolytic action.
Keywords: Glyceryl trinitrate; excisional wound; wound contraction; epithelization Back to TOC