Afatinib Associated Papulopustular Phototoxic Eruptions- A Novel Case Report
U. Zeenath Begum, M. Krishnakanth, Gayathri Rajesh, Mahalakshmi Veeraraghavan, Sudha R and S. MuruganDepartment of Dermatology, Sri Ramachandra Institute of Higher Education and Research, Porur,Chennai -600 016, India
Corresponding Author E-mail: zeenathbe@gmail.com
Abstract: Non Small Cell Lung Cancer(NSCLC) is the most common type of Lung Cancer. It is characterized by multiple mutations, the commonest being the EGFR and KRAS. Afatinib is an immaculate drug used in Non-Small Cell Lung Cancer, with EGFR mutations. Here we are presenting a case of a 70 year old male, with Non-Small Cell Lung Carcinoma, started on Afatinib, who subsequently developed multiple raised skin lesions over the face, neck and the upper chest. On examination, multiple crusted papules and pustules over the face and anterior chest were present. A diagnosis of Photo distributed Acneiform Eruption secondary to Afatinib was made. Patient was treated appropriately and lesions subsided with post inflammatory hyperpigmentation.This article highlights the characteristic Afatinib induced papulo – pustular eruptions, which eventually responded to treatment.
Keywords: Afatinib; EGFR Mutations; Non Small Cell Lung Carcinoma; Phototoxic Eruptions; Rarely Reported; Responded to Treatment Back to TOC