In-Vitro Anti-Proliferative Effects of Ethanolic Extract of Vanilla Planifolia Leaf Extract Against A431 Human Epidermoid Carcinoma Cells
Vijaybabu K1 and Punnagai K21Department of Pharmacology Annapoorna Medical College and Hospital Salem 636302, Tamil Nadu, India.
2Department of Pharmacology, Sri Ramachandra Medical College and Hospital Sri Ramachandra Institute of Higher education and Research (Deemed to be University) Porur Chennai Tamil Nadu, India.
Corresponding Author E-mail: punnagaiguna@hotmail.com
Abstract: Squamous cell carcinoma is the second largest among skin cancer diseases. The aim of the present study is to reveal the antiproliferative property of vanilla leaf extract against A431 cells. Antiproliferative property was assessed by MTT assay. Apoptotic property was assessed by DNA fragmentation assay. Antiproliferative property of extract was revealed in a dose dependent manner. IC50 of the extract against A431 cells was revealed at 31.2µg/ml. This study revealed the cancer suppression capability of vanilla leaf extract in skin cancer cell lines.
Keywords: A431 Cell Lines; DNA Fragmentation; MTT Assay; Vanilla Leaf Extract Back to TOC