Evaluation of Biochemical Markers and Oxidative Stress in Females of Acute Renal Failure
Drutpal Singh Baghel1, Adesh Patidar2 and Bhaskar Reddy31Department of Biochemistry, S. S. Medical College, Rewa, India.
2Department of Pharmacology, S. S. Medical College, Rewa, India.
3Department of Anatomy, S. S. Medical College, Rewa, India.
Abstract: Acute renal failure is a challenging problem. Acute renal failure as the complication of in-patient care is connected with worsened survival, increased morbidity and cost of hospitalization. Reactive oxygen intermediates have been demonstrated to play an etiological role in renal failure. Renal failure term primarily denotes failure of the excretory functions of the kidney, leading to retention of nitrogenous waste products of metabolism. The present study was undertaken to evaluate and compare the severity of serum electrolytes, glucose, protein, creatinine, urea, antioxidant enzymes and oxidant products in females suffering from acute renal failure. For the present study, 58 female subjects of acute renal failure aged from 30 - 80 years and 60 control subjects of same age group healthy females were assessed. A Significant (P<0.001) increase in serum potassium, creatinine, urea, and plasma malondialdehyde levels were found in females with acute renal failure groups while serum sodium, protein and antioxidant enzymes were found to be decreased significantly (P<0.001) when compared to female healthy control groups. This review also discuss diagnostic tools, strategies for improved design of clinical and therapeutic interventions that will be needed to properly treat acute renal failure in the 21st century.
Keywords: Acute renal failure; oxidative stress Back to TOC