Evaluation of Alpha-Glucosidase Inhibitory Activity of Vinca Rosea
Anand Priya V. V. M, K. Kranthi, K. Punnagai and Darling Chellathai DavidDepartment of Pharmacology, Sri Ramachandra Medical College and Research Institute, SRIHER, Porur, Chennai, India.
Corresponding author E-mail: drkranthi10@gmail.com
Abstract: Diabetes mellitus (DM) has developed into serious health problem worldwide. α-glucosidase inhibitors are used in management of Type II Diabetes mellitus. Medicinal plants are known to be effective in treating various diseases and disorders. Catharanthus roseus belonging to family Apocyanaceae is very well known for its anticancer property. The present study was aimed to compare the alpha glucosidase inhibitory effect of leaves and flowers extracts of Vinca rosea by an in-vitro assay. Methanolic extracts were obtained using Soxhlet apparatus. Yeast alpha glucosidase was used as the enzyme source. Acarbose was used as the reference drug. The % inhibition was calculated. The results proved that both leaves and flowers extract of Vinca rosea possess α-glucosidase inhibitor activity. The leaf extract (57.87%) showed a better activity when compared to flower extracts (48.31%). The result supports Vinca rosea as a potential source in treating Diabetes mellitus.
Keywords: α-Glucosidase; Acarbose; Anticancer; Apocyanaceae; Catharanthus Roseus; Diabetes Mellitus Back to TOC