Effect of Sodium Tetraborate on Oxidative Damages in Heart Tissue in Chromium Intoxication
Marat Iztleuov1, Gulnara Temirova2, Muslima Bashbayeva3, Zhanat Komyekbay2, Yerbolat Iztleuov4*, Zhanibyek Madikhan1 and Gulmira Yemzharova1

1Department of Natural Sciences, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

2Department of Gystology, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

3Continuing Professional Development Center, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

4Department of Radiation diagnostics, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

Corresponding Author E-mail: ermar80@mail.ru

Abstract: The cardioprotective effects of sodium tetraborate in chromium intoxication, correction of lipid profile and oxidative stress have been investigated. The experiment has been performed on 36 Wistar male rats, divided into 6 groups. I - control; II, III, and IV groups received potassium bichromate (K2Cr2O7) 700 mg/l with drinking water; rats of the III and IV groups received additionally orally a solution of sodium tetraborate (Na2B7O7) in doses of 22.5 mg/kg and 225 mg/kg per day, respectively. Animals of the V and VI groups received orally only Na2B7O7 solution at the rate respectively 22.5 and 225 mg/kg weight per day. The study duration was 21 days. The introduction of K2Cr2O7 increases content of malondialdehyde and carbonial protein in cardiac tissue, activates the antioxidant system of the heart, expands the levels of biomarkers of cardiotoxicity and increases the atherogenic index. The introduction of Na2B7O7 (22.5 mg/kg) reduces the toxic effect of K2Cr2O7 (cardioprotective effect). The use of Na2B4O7 (225 mg/kg) does not give a positive effect. In the group receiving only Na2B4O7 (22.5 mg/kg), inhibition of lipid oxidation and protein is observed, decrease of toxicity of biomarkers and low density lipoprotein-cholesterol (LDL-C), i.e. antioxidant effect. On the contrary Na2B4O7 (225 mg/kg) shows the prooxidant property.

Keywords: Heart; Lipid Profile; Oxidative Stress; Potassium Bichromate; Protective Effect; Rats; Sodium Tetraborate

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