Antibacterial Activity of Hoya Diversifolia Ethanolic Leaves Extract

Nurhidayah Ab-Rahim*¹, Wan Ismahanisa Ismail¹, Muhammad Nabil Fikri Roslan¹, Mohd Hafiz Mail², Roz Azinur Che Lamin³ and Salmah Ismail⁴

¹Fakulti Sains Kesihatan, Universiti Teknologi MARA, Cawangan Pulau Pinang (Kampus Bertam), Malaysia.

²Malaysian Institute Pharmaceuticals and Nutraceuticals (IPHARM), NIBM, Pulau Pinang, Malaysia.

³Fakulti Farmasi, Universiti Teknologi MARA, Cawangan Pulau Pinang (Kampus Bertam), Malaysia.

⁴Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur.

Corresponding author email: hidayahr@uitm.edu.my

Abstract: The rapid emergence of resistance bacteria toward various antibiotics may associate with higher medical cost and increase mortality rate. Hoya diversifolia was used to cure skin diseases and alleviate rheumatism pain. The aim of this study is to evaluate in vitro antibacterial properties of H. diversifolia ethanolic leaves extract against several Gram positive and Gram negative bacteria. The antibacterial study was determined based on pattern of inhibition zones using disc diffusion assay and also minimal inhibitory concentration (MIC). It is shown that the extract can inhibit the growth of methicillin-resistant Staphylococcus aureus, Escherichia coli and Bacillus cereus. The lowest MIC values of extract were 25 mg/mL for MRSA and E. coli as well as 100 mg/mL for B. cereus at 24 and 48 hours of incubation period. The plant had potential to act as antibacterial agent that can be applied in pharmaceutical and cosmetic fields.

Keywords: Antibacterial; Disc Diffusion; Hoya Diversifolia; Minimum Inhibitory Concentration

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