Phytoconstituents and Hepatoprotective Effect of Suaeda Monoica Forssk and Suaeda Pruinosa Lange
Elsharabasy F. S1, Metwally N. S2, Mahmoud A. H2, Soliman M. S2, Youness E. R*3, Farrag, A. H4 and Sherifa Arafa51Department of Chemistry, Prince Sattam Bin Abdul-Aziz University, Saudi Arabia and Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Egypt.
2Therapeutic Chemistry Department, Pharmaceutical Industries Research Division, National Research Center, Dokki, Egypt.
3Medical Biochemistry Department, Medical Research division, National Research Center, Dokki, Egypt.
4Pathology Department, National Research Center, Dokki, Egypt.
5Department of Biology, Prince Sattam Bin Abdulaziz University, Saudi Arabia and Department of Botany, Faculty of Science, Cairo University, Egypt.
Corresponding Author E-mail: hoctober2000@yahoo.com
Abstract: The objective of this study is to investigate the chemical constituents of Suaeda monoica and Suaeda pruinosa and evaluate their effects on rat liver intoxicated by over dose of paracetamol. Qualitative analysis of (80%) methanol in water fraction revealed the presence of alkaloids, terpenoids, steroids, tannins, quinones, saponins, flavonoids and phenols from two mangrove species of S. monoica and S. pruinosa was carried out. The compounds were identified from the 80% methanol-H2O fraction as Rutin, quercetin, Syringic acid, Coffeic acid, Catechin, Coumaric acid, Vanillin, Gallic acid, Cinnamic acid. Amino acids analysis for the methanolic extract from the aerial parts of Suaeda monoica and Suaeda pruinosa showed the presence of thirteen amino acids and absence of valine, Isoleucine, Phenylalanine. Fatty acid analysis of lipids showed high percentage of long chain fatty acids.TLC of the lipoidal matter for each plant showed the presence β-amyrin, β-sitosterol and stigmasterol. Toxicity was stimulated by administration of a single oral dose of paracetamol (3 g/kg body weight). The extract of the aerial parts of plants (100 mg/kg) was utilized on a pre-and post-treatment basis. Both extracts significantly improved liver and kidney function with prophylactic or therapeutic treatments. Histopathological and histochemical studies showed parallel effects with the biochemical measured parameters.
Keywords: Hepatoprotection; Paracetamol; Secondary Metabolites; Suaeda Sp. Back to TOC