Estimation of Biochemical Parameters of Lipid Metabolism In Diabetics
Manishi Singh1, Manika Singh2 and M. P Singh31Department of Medical Biochemistry, Chiraiyu Medical College, Bhopal 2Department of Oral Medicine and Radiology, Rishi Raj Dental College and Research Centre, Bhopal, India. Department of Conservative Dentistry, People’s College of Dental Science’s and Research Centre, Bhopal, India.
Abstract: In this present study included 40 morbid and 50 healthy control all were in age group of 20 to 60 years having renal failure of various etiology but in this study group patients of diabetes with ESRD studied, male, female ratio 3:2, lipid profile, blood sugar, apolipoprotein A and B were estimated by fully automated clinical chemistry analyzer, orion diagnostic immuno chemical assay and blood sugar by GOD, POD method. It was found that patient of ESRD with diabetes had HDL-chol, APO A1, APO A1/APO B, HDL Chol./T.Chol. was significantly decreased (p <0.05) as compared to control. Same time T-Chol., TG, LDL-Chol., VLDL-Chol, APO-B, LDL-Chol/HDL-Chol., APO B/A1, significantly increased (p<0.05) as compared to control. It can be concluded from the present study that patient of ESRD with diabetes had significantly decreased level of HDL-Chol, APO A1, APO A1/ APO B, and significantly increased level of TG, VLDL, APO B/APO A1, ratio on atherogenic index was evaluated in all patient dialyzed and undialyzed in both groups. Indicated that atherogenic changes is more advanced in diabetic than in non diabetics with ESRD, this is the scope of dyslipidemia in diabetics with nephropathy is an addition to the effect of basic disease.
Keywords: Hyperlipidemia; Hyperglycemia; Lipid metabolism;Lipids; ESRD Back to TOC