Anticonvulsant Activity of Aqueous Extract of Aquilaria Agallocha
Ritesh Jain1*, K. Nandakumar1, Vishal Srivastava1, Santosh Kumar Vaidya1, Shailesh Patel1, Pradeep Kumar² and Lalit Kumar¹Department of Pharmacology, P.E.S College of Pharmacy, Bangalore.
²Department of Pharmaceutical Analysis, P.E.S. Collage of Pharmacy, Bangalore, (India).
³Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Karnataka.
Abstract: Anticonvulsant activity of the aqueous extracts of Aquilaria agallocha Roxb. family Thymelaeceae was studied in Swiss albino mice using the Pentylene tetrazole (PTZ) and Maximal electroshock (MES) convulsion.In Pentylene tetrazole (PTZ) induced convulsion model, aqueous extracts of Aquilaria agallocha (AQAA) 300 and 600 mg/kg, p.o doses significantly increased both the onset of clonus and tonic convulsions induced by PTZ. The effect was dose dependent. In Maximal electroshock (MES) induced convulsion model, 300 mg/kg dose of AQAA exhibited significant anti convulsant effect, there is significant decrease in the duration of extensor phase with increase in the latency of clonus convulsion. The 600 mg/kg of AQAA also increased the latency of clonus in both acute and chronic studies and decreased the duration of extensor phase. From the experimental study it can be concluded that aqueous extract of heartwood of Aquilaria agallocha had exhibited significant anticonvulsant activity in mice.
Keywords: Aquilaria agallocha; Convulsion; Pentylene tetrazole (PTZ); Maximal electroshock (MES) Back to TOC