Genotoxicity of Newly Synthesised Imidazole-2(2-2 benzylidene hydrazinyl)-5,5 diphenyl-1,5dihydro -4-imidazol-4one(4-chloro derivative)
G. E. Suhasini, M. Nirmala, Rashmi Shiva Kumar and Archana GiriJNTU, Hyderabad, India.
Abstract: The newly synthesised 2-(2-2 benzylidene hydrazinyl)-5,5 diphenyl-1,5dihydro -4-imidazol-4one was found to have anthelmintic, ,antibacterial and antifungal activity . Since the Compound has the potential for further development .Genotoxicity of the new Compound was studied for visible changes to chromosome structure and morphology .They have played a very important part as indicators of genetic damage in both clinical and cancer studies. The Chromosome Aberration Assay Invitro is a useful and sensitive test for detection of Genotoxins .There are four common types of structural Chromosome Aberrations are 1.Deletions 2.Duplications 3.Inversions 4.Translocations. Micronuclei are indicators for fixed genomic damage in cells .The Synthesised compound did not show any Chromosomal Aberrations or formation Micronuclei
Keywords: Genotoxicity; Mutagenecity; Chromosomal aberrations; Micro nuclei; Carcinogenecity Back to TOC