Role of Inulin in the Protection and Management of Metabolic Inflammation in Humans by

Wassef Girgiss Nicola¹, Mina Wassef Girgiss¹, Aly Mohamed Ezz El-Arab², Dawoud Fakhry Habib³, Mohamed Elsayed Elnemr⁴, Nadia Mohamed Ahmed³ and Eman Refaat Youness³

¹Internal Medicine, Endocrinology and metabolism-Department of Internal Medicine, Medical Division, National Research Centre (NRC), Cairo, Egypt.

²Nutrition-Department of Nutrition and Food Science, National Research Centre (NRC), Cairo, Egypt.

³Biochemistry-Medical Biochemistry Department, Medical Division, National Research Centre (NRC), Cairo, Egypt.

⁴Internal Medicine, Department of Internal Medicine, 6th October University-Egypt.

Corresponding Author E-mail: mwgnicola@hotmail.com

Abstract: Systemic inflammation describes certain metabolic alterations which are mediated by inflammatory cytokines. Theses occur essentially as a defensive body response towards offending agents such as surplus nutrient staffs. Our aim is to find out the role of inulin as a protective agent against metabolic inflammation. Twenty eight type 2 diabetic females were subjected to the estimation of their serum high sensitivity C-reactive protein, lipopolysaccharides, tumor necrosis factor alpha, adiponectin and HOMA-IR test before and after three weeks of inulin ingestion. There was a significant drop in the level of serum high sensitivity C-reactive protein, lipopolysaccharides, tumor necrosis factor alpha, HOMA-IR and a non-significant rise in serum adiponectin after inulin ingestion. In summary inulin can act as a useful protective agent in systemic inflammation.

Keywords: Adiponectin;  Tumor Necrosis Factor Alpha  HOMA-IR;  High Sensitivity C-reactive Protein; Inulin; Lipopolysaccharides; Metabolic Inflammation;

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