Protective Effect of Sodium Tetraborate on Chromium-induced Brain Damage in Rats

Yerbolat Iztleuov¹, Talgar Abilov², Ganiya Zhanabayeva³, Irina Ismailova⁴ and Marat Iztleuov²

¹Department of Radiation diagnostics, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

²Department of Natural sciences, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

³Department of General dentist, Faculty of Stomatology, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

⁴Department of General medical practice, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.

Corresponding Author E-mail: ermar80@mail.ru

Abstract: Hexavalent chromium presents a particular threat due to its high toxicity. In this study showed the neuroprotective effect of sodium tetraborate in chromic intoxication. The experiment was performed on Wistar rats divided into 4 groups: 1 group - control; 2 group - single intraperitoneal injection of K₂Сr₂O₇ in a dose of 0,5LD₅₀, in the 3 and 4 groups with drinking water received Na₂B₄O₇. Animals of the 3 group - 4 mg/kg of body weight, in 4 group - 72 mg/kg of body weight daily for 10 days, the last administration of Na₂B₄O₇ was combined with a single intraperitoneal injection of K₂Сr₂O₇ at a dose of 14 mg/kg (0,5LD₅₀). Na₂B₄O₇ in a dose of 4 mg/kg leads to a decrease in the level of MDA by 33%, an increase in the activity of catalase by 69%, superoxide dismutase by 21%, GR by 49%. Na₂B₄O₇ at a dose of 72 mg/kg increases the MDA content by 31% in comparison with the data of rats of chromic intoxication. K₂Сr₂O₇ reduces the GSH level by 42%, the non-protein thiol by 36%. Na₂B₄O₇ at a dose of 4 mg/kg increased the GSH level by 53%, the non-protein thiol by 35%, and at a dose of 72 mg/kg reduced the GSH content by 23% (ρ<0.05), the non-protein thiol by 20% (ρ<0.05) in comparison with the data of rats exposed to K₂Сr₂O₇.

Keywords: Antioxidant System Bichromate Potassium; Brain Damage; Lipid Peroxidation; Sodium Tetraborate;

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