Insilico Modeling of Vascular Endothelial Growth Factor and its Interaction with Inhibitor Terrein
R. MensudarDepartment of Conservative Dentistry and Endodontics, Sree Balaji Dental College and Hospitals, Chennai (India)
Abstract: Objective Today with the advent of dental bioinformatics, a scientific revolution has evolved in the field of cell and molecular biology, which have given an important contribution by showing the phenomena that occur at the cellular level and elucidating the behaviour of various signals and messengers. The purpose of this study was to develop the insilico model of vascular endothelial growth factor and to determine its interaction with an inhibitor protein, Terrein. Material and Methods The structure of VEGF from Homo sapiens was modelled using Modeler9v3 software. Validation of the modelled structure was done through Procheck. The Q-Site Finder recommends the active site of VEGF and the detailed docking analysis of the complex structure and its interaction energies with Terrein was derived by the docking study using Auto Dock. Results The analysis of the results strongly suggests the potential role of terrain as an anti-inflammatory modulator in pulpal inflammation. Conclusion Within the limitations of the present study, it was concluded that Terrein is a potent anti-inflammatory modulator and play a vital role in the pathogenesis of pulpal inflammation by inhibiting the key regulating growth factor (VEGF).
Keywords: Pulpitis, terrein; vascular endothelial growth facto; bioinformatics; dental pulp; angiogenesis Back to TOC