Biochemical Changes Related with Temporomandibular Joint Disorders and Inflammatory Arthritis
Huda Shakir Ahmed
Department of Oral Diagnosis, College of Dentistry/ University of Baghdad.
Corresponding Author E-mail: hindshakir82@gmail.com
Abstract: This study aimed to determine vitamin D, calcium, total alkaline phosphatase activity, and interleukin-1 in sera of temporomandibular joints disorder patients suffer from rheumatoid arthritis. The present study conducted 45 temporomandibular disorder patients with rheumatoid arthritis. While remaining 45 apparently healthy subjects were selected as controls. There was a significant decrease in vitamin D in temporomandibular disorder patients as compared to the controls, (P=0.001). While a significant increase in serum total alkaline phosphatase activity and interleukin-1 in temporomandibular disorder patients as compared to the controls, (P=0.01). There was a decrease in serum calcium levels in temporomandibular disorder patients as compared to the controls, but it was not significant. There was a significant negative correlation between serum vitamin D activity with total alkaline phosphatase activity and interleukin-1 in temporomandibular disorder patients, (P=0.001). This study demonstrated that serum vitamin D levels were significantly lower in temporomandibular disorder patients with RA. Also, there was a significant increase in serum total alkaline phosphatase as bone marker and interleukin-1 in temporomandibular disorder patients which provide a more reliable and complete profile of inflammatory contributors to temporomandibular disorder.
Keywords: Interleukin-1 Temporomandibular Joint; Rheumatoid Arthritis; Back to TOC