Atherosclerotic Regulation of Asparagus racemosus Root Extract on Lipid Profile in Male Swiss Albino Mice, Subjected to Inorganic Lead Compound
Veena Sharma¹*, Ritu Bala Verma¹ and Shatruhan Sharma²¹Department of Bioscience and Biotechnology, Banasthali University, Banasthali - 304 022 India. ²MAI-Jaipur-12, Rajasthan India.
Abstract: The present study has been made to reveal the regulatory action of Asparagus racemosus on inorganic lead induced toxicity in the Swiss albino mice (Mus Musculus). The experiment design with thirty-six male Swiss albino mice with the average weight 29 g, were divided into six experimental groups and each group with six mice. Group I – (Control; Without any treatment), Group II- (Lead nitrate;20 mg/Kg body weight, orally), Group III- (ARRE; 50mg/Kg body weight, orally), Group IV- (ARRE;150mg/Kg body weight, orally), Group V- (Lead nitrate;20 mg/Kg body weight, orally+ ARRE; 50mg/Kg body weight, orally), Group VI- (Lead nitrate;20 mg/Kg body weight, orally +ARRE;150mg/Kg body weight, orally) respectively treated for 45 days. Administration of lead nitrate for 45 days increased the plasma total cholesterol (TC), triglyceride (TG) and LDL-cholesterol; however VLDL-cholesterol and HDL-cholesterol values are low in lead exposed subjects. Individual and simultaneous administration of ARRE along with lead for the both doses, Asparagus racemosus showed the positive amelioration in lipid profile at different levels to some extent with all variables. The findings of present study suggest the possible hypercholestramic abnormalities induced by lead can be neutralized by Asparagus racemosus in the lead exposed population.
Keywords: Lead nitrate; Asparagus racemosus; lipid profile; lipoprotein levels; Mice Back to TOC