The Effect of Kemuning Leaves (Murraya Paniculata (L.) Jack) Infusion on SGOT and SGPT Enzym Activities in Obese Patients

Asep Sukohar¹, Azzren Virgita Pasya², Tri Umiana Soleha³ and Putu Ristyaning Ayu Sangging⁴

¹Departement of Pharmacology, Faculty of Medicine, Lampung University, Lampung, Indonesia.

²Faculty of Medicine, Lampung University, Lampung, Indonesia.

³Departement of Microbiology, Faculty of Medicine, Lampung University, Lampung, Indonesia.

⁴Departement of Clinical Pathology, Faculty of Medicine, Lampung University, Lampung, Indonesia.

Coresponding Author E-mail asepsukohar@gmail.com

Abstract: Obesity or excess body weight may cause fatty liver that can be diagnosed by the increase of SGOT and SGPT enzymes activity. Kemuning leaves, not only act as antiobesity, but also act as hepatoprotecor from its content of flavonoid which act as an antioxidant to liver cells. The aim of this research is to know the effect of kemuning leaves (Murraya paniculata (L.) Jack) infusion to SGOT and SGPT enzymes activity in obese patients.This study used 15 obese male aged 25-50 years as participants. The patients was given a 250 mL kemuning leaves infusion treatment twice a day after meal for 15 days. SGOT and SGPT enzymes serum level of participants were measured and compared before and after consumption of kemuning leaves infusion. The average value of SGOT pretest is 35,87 U/l, SGPT 41,20 U/l, and postest SGOT 25,47 U/l, SGPT 31,67 U/l with Paired T test bivariate analysis of SGOT p=0,011 and SGPT p=0,032. Kemuning leaves infusion could decrease SGOT and SGPT enzymes activity in obese patients.

Keywords: Infusion; kemuning leaves; murraya paniculata; obesity; SGOT; SGPT

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