Synthesis, Characterization Of Some New 1- (2, 5 - Dichloro Phenyl Hydrazino)-3,5-Dimethyl- 4-(Substituted Phenyl Azo) Pyrazoles And 3,5-Dimethyl- 4-(Substituted Phenyl Benzene Azo) Isoxazoles As Anti-Bacterial Agents

Alok K. Pareek*, P. E. Joseph and Daya S. Seth

School of Chemical Sciences, Department of Chemistry, ST. John’s College, Agra - 282002 India.

Abstract:

Pyrazole is an important class of organic molecules and containing two nitrogen-atoms in five membered parent ring. In this synthesis approach features, newly substituted pyrazoles has been synthesized by condensation reactions between various substituted benzene-azo acetyl acetone (1a-1t) and substituted phenyl hydrazine with few drops of glacial acetic acid used as catalyst in alcoholic medium and substituted isoxazoles have been synthesized by the condensation reactions of subs. benzene-azo acetyl acetone (1a-1b) with hydroxyl amine hydrochloride and sodium acetate in the alcoholic medium. The structures of newly synthesized substituted pyrazoles and substituted isoxazoles were established on the basis of their spectral studies like IR, ¹H NMR, Elemental Analysis, physical properties. The newly synthesized compounds were screened for their anti-bacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords:

Subs. benzene-azo acetyl acetone; Subs. Phenyl hydrazine; Pyrazoles; Isoxazoles; Antibacterial activity

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