Is There any Relationship Between Serum Level of Vitamin D and Postoperative Hypocalcemia after total Thyroidectomy?
Alireza Abdollahi, Manoucher Nakhjavani, Abbas Alibakhshi and Mahtab MohammadifardDepartment of Pathology, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Corresponding Author E-mail: abdollahi_a@tums.ac.ir
Abstract: Total thyroidectomy, is widely used as the selective treatment for benign and malignant thyroid diseases. Postoperative indication of Hypocalcemia was reported as 1-50%. Recently, the role of vitamin D in incidence of Hypocalcemia after thyroidectomy has been taken into consideration. This study was conducted on volunteered patients at Imam Khomeini hospital complex and it aimed at surveying the serum level of preoperative Vitamin D before total thyroidectomy surgery and its relationship with the incidence of postoperative Hypocalcemia after the surgery. The study was done on 57 patients after they had total thyroidectomy surgery. Preoperative Vitamin D, PTH and Albumin were measured in all the patients. Also, Calcium was measured on the first and second days after surgery and the results obtained were then analyzed. Average preoperative and intraoperative calcium were significantly different (P<0.001). Moreover, a significant difference was observed between preoperative and postoperative (after 2 days) calcium (P<0.001). Considering the cut-off point as 8.6, forty patients (72%) faced postoperative Hypocalcemia after one day and seventeen patients (29.7%) had normal calcium levels in blood. Preoperative calcium levels and postoperative PTH in people having Hypocalcemia were significantly less than in those with normal calcium levels. Thirty seven patients (64.9%) had normal preoperative Vitamin D and twenty patients (35.1%) had Vitamin D insufficiency. Of thirty-seven patients having normal vitamin D in serum, twenty-six people had postoperative Hypocalcemia on the first day. Also, of twenty patients with insufficient vitamin D, fourteen patients got Hypocalcemia, of which the difference was not statistically significant. There was no relationship between serum levels of Vitamin D and Hypocalcemia after total Thyroidectomy surgery.
Keywords: Vitamin D; Total thyroidectomy; Hypocalcemia Back to TOC