Novel Synthesis, Characterization of some New Substituted Coumarin and Schiff Base, Substituted benzo-coumarin and benzo-Schiff Base and Study of their Antibacterial Activities
Alok. Pareek*, P. E. Joseph and Daya S. Seth
School of Chemical Sciences, Department of Chemistry, ST. John’s College, Agra - 282002 India.
Abstract:
A simple synthesis of various substituted coumarin and Schiff base was prepared by the condensation reactions of (R) phenyl malon anilic acid (1a, 2a) with different substituted salicylald ehydes in the presence of pyridine as a catalyst at maintained temperature. Substituted benzo-coumarin and benzo-Schiff base has been synthesized by the condensation reactions of (R) malon anilic acid (1a, 2a) with 2-hydroxy-1-Naphthaldehyde in the presence of pyridine. The constitution of the newly synthesized compounds are characterized by their spectral studies like IR, 1H NMR, elemental analysis, physical properties. Further they were assayed for their antibacterial activity against one Gram + ve S.aureus and one Gram - ve E.coli micro-organism.
Keywords:Substituted Coumarin and Schiff base; Benzo-coumarin and Benzo-Schiff base; Pyridine; Malonic acid
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