New Naphthalene-Derivative as Cardioprotector Drug on the Ischemia/Reperfusion Injury

¹Lauro Figueroa-Valverde^*, 3Marcela Rosas-Nexticapa, ²Francisco Díaz-Cedillo, ¹Lenin Hau-Heredia, ¹Elodia García-Cervera, ¹Eduardo Pool-Gómez¹, ⁴Rolando García-Martínez, and ⁵Abelardo amacho-Luis.

¹Laboratory of Pharmacochemistry, Faculty of Chemical and Biological Sciences; University Autonomous of Campeche. Av. Agustín Melgar, Col Buenavista C.P. 24039, Campeche Cam., México. ²Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340. ³Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz, México. ⁴Laboratorio de Neurociencias del Centro de Investigaciones Biomédicas de la Universidad Autónoma de Campeche. Av. Patricio Trueba y Regil s/n, Col. Lindavista C.P. 24090, Campeche Cam., México. ⁵Facultad de Medicina y Nutrición, Centro Investigación en alimentos y nutrición. Universidad Juárez del Estado de Durango.  Av. Universidad s/n esq. Fanny Anitua, Zona centro. Durango, México.

Abstract: There is scarce information about the effects exerted by the naphthalene derivatives on cardiac injury caused by ischemia/reperfusion.  In this study, a new naphthalene derivative was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the naphthalene derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the naphthalene derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; propanolol, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the naphthalene derivative reduces infarct size compared with control. Other results showed that the naphthalene derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. In addition, other data indicate that the naphthalene derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that naphthalene derivative exert a cardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.

Keywords: Naphthalene; left ventricular pressure; nifedipine

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