Antifungal Activity of Pterocarpus Santalinus an In Vitro Study
Arokiyaraj and K. PerinbamDepartment of Biomedical Engineering, Sathyabama University, Chennai - 119 (India).
Abstract:
In the present study leaves of Pterocarpus santalinus L.f (Fabaceae) were exhaustively extracted with different solvents like hexane, ethyl acetate and methanol in ascending order of polarity. All the three extract was subjected to antifungal screening and phytochemical analysis. The ethyl acetate extract showed significant MIC values against Trichophyton rubrum (62.5 µg/ml), Trichophyton mentagrophytes (500 µg/ml), Trichophyton simmi (125 µg/ml), Epidermophyton floccosum (500 µg/ml) and Scropulariopsis sp (500 µg/ml). Phytochemical screening revealed the presence of terpenoids, steroids, flavonoids, alkaloids, tannins and carbohydrates. The present study validates the traditional use of the medicinal plant and indicates that it can be effective potential candidate for the development of new antifungal drug to treat fungal infections.
Keywords:Antifungal; dermatophytes; Pterocarpus santalinus; minimum inhibitory concentration
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