Development and Evaluation of Iosartan Potassium Sustained Release Matrix Tablet using Hydrophilic and Hydrophobic Polymers
S. Padmapriya*, J. Kausalya, V. Vaijayanthi, S. K. Umadevi, Deepak Patil and B. SenthilnathanVels College of Pharmacy, Pallavaram, Chennai- 117 India.
Abstract: The present study was to develop sustained release matrix tablet of Losartan potassium a potent first angiotensin antagonist, using hydrophilic and hydrophobic polymers (HPMC, SCMC and EC) alone and in combination in the ratio 1:1. Preformulation studies were carried out to rule out interaction between drug and polymer. The granules (six formulations) were prepared by wet granulation method and evaluated for Bulk Density, Angle of repose, CI, Total porosity and drug content. The granules showed satisfactory flow properties, compressibility and drug content. The granules were then compressed into tablets and subjected to thickness, weight variation, hardness, drug content and in vitro release studies. All the tablet formulation showed acceptable pharmacotechnical properties and compliance with in-house specifications for tested parameters. The result of vitro release study revealed that formulation containing hydrophilic and hydrophobic polymers combination showed sustained release characters with diffusion coupled erosion mechanism.
Keywords: Sustained release; matrix tablet; Losartan potassium; hydrophilic; hydrophobic polymers Back to TOC