Oxidative Stress in Secondary Nephrotic Syndrome: Recent Advances with Homocysteine, Copper and Zinc
Jyoti Dwivedi¹ and Purnima Dey Sarkar²¹Department of Biochemistry, S.S. Medical College Rewa - 486 001 India.
²Department of Biochemistry, N.S.C.B. Medical College Jabalpur - 482 003 India.
Corresponding Author E-mail:jyoti.bioc@rediffmail.com
Abstract: Imbalance in oxidant/antioxidant status is well document in patients with nephrotic syndrome & secondary nephrotic syndrome. Serum total antioxidant capacity, malondialdehyde, homocysteine, copper, zinc, plasma vitamin C were estimated in 2 groups, group I comprised of 50 nephrotic syndrome patients and group II comprised of 41 secondary nephrotic syndrome patients. It was observed there were decreased level of serum total antioxidant capacity (P<0.0001), copper (P<0.02), zinc (P<0.02), plasma vitamin C (P<0.0001) and increased serum level of malondialdehyde, homocysteine (P<0.0001) in secondary nephrotic group II when compared to nephrotic group I. Serum homocysteine were significantly positive correlated with MDA, negative correlated with serum Cu & Zn in nephrotic group. In conclusion increased oxidative stress in secondary nephrotic syndrome than nephrotic syndrome. Hyperhomocyst(e)inemia is related to decrease concentration of copper, zinc and supported to oxidative stress & endothelial dysfunction in nephrotic syndrome and secondary nephrotic syndrome.
Keywords: Nephrotic Syndrome; Total antioxidant capacity; Homocysteine; Malondialdehyde Back to TOC