A Convenient Procedure for the Asymmetric Reduction of Prochiral ketones using TetrabutylammoniumFfluoride, Polymethylhydrosiloxane and Biocatalysts, Baker’s Yeast
Lakhdar Sekhri* and NedjimiDepartment of Chemistry, University of Ouargla - 300 00 Algeria.
Abstract: A range of prochiral acetophenone derivatives have been converted efficiently to the corresponding (R)- alcohols with > 80% yield and good enantioselectivities (up to 70% ee). Cyclic ketones are also reduced with high levels of stereoselectivity with PMHS in the presence of TBAF and baker’s yeast, in particular 4-methylcyclohaxanone (trans: cis 84:16). High stereoselectivity is also observed in the reduction of 2-cyanobenzaldehyde and anti-imine was obtained in 71%.
Keywords: Asymmetric reduction; biocatalyst; backer’s yeast; TBAF, PMHS Back to TOC