Anti Inflammation and Anti Oxidant Effect of Active Agent Polysaccharide Peptide (Ganoderma Lucidum) in Preventing Atherosclerotic Diseases

Djanggan Sargowo^1,4, Indra Prasetya¹, Ria Ashriyah¹, Ira Setyawati¹, W Titin Andri², Teuku Heriansyah³

¹Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University / Dr. Saiful Anwar Hospital, Malang ²Department of Nursery, Faculty of Medicine, Brawijaya University, Malang ³Department of Cardiology and Vascular Medicine, Faculty of Medicine, Syiah Kuala University / Dr. Zainoel Abidin Hospital, Banda Aceh ⁴Department of Internal Medicine, Faculty of Medicine, Brawijaya University / Dr. Saiful Anwar Hospital, Malang. Jaksa Agung Suprapto Street, no. 2, Malang 65111, Indonesia *Corresponding author E-mail: djanggan@yahoo.com

Abstract: This study was aimed to evaluate anti-inflammatory and antioxidant effect of polysaccharide peptide (PsP) from Ganoderma lucidum in atherosclerosis. The atherosclerotic rats were randomly divided into four groups (5 rats each group) : atherosclerotic model with high-fat diet, low dose PsP treated group (50 mg/kgBW), medium dose PsP treated group (150 mg/kgBW), high dose PsP treated group (300 mg/kgBW), with normal mice used as a control group. Parameters measured were the level of MDA, SOD, IL - 6 , IL - 10, hsCRP, TNF - α, lipid profile and foam cell. After PsP therapy for 5 weeks, the levels of MDA (p=0.01), hsCRP (p=0.018) in rats model of atherosclerosis decrease significantly. PsP can reduce levels of IL - 6 (p=0.933) and increase levels of SOD (p=0.28) descriptively at PsP doses 150 mg/kgBW. While the levels of TNF-α (p=0.894) and IL-10 (p=0.98) was not affected by administration of PsP. PsP improve the lipid profile by increasing HDL (p=0.002) and lowering total cholesterol (p=0.04). The formation of foam cells (p=0.024) as a marker of atherogenesis significantly decreased by administration of PsP. PSP can be useful to reduce inflammatory processes and oxidative stress to prevent atherogenesis .

Keywords: polysaccharide peptide (Ganoderma lucidum); anti-inflammation; anti oxidant; cardiovascular disease; atherosclerosis

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