Pulsatile Drug Delivery System
V. Ravichandiran1, V. Suba1, B. Senthilnathan*1, K. Rajachandrika1, S. Padmapriya1, T. Saraswathy21Vels college of Pharmacy, Pallavaram, Chennai India.
2Lecturer,Madras Medical College, Chennai - 3 India.
Corresponding Author E-mail:sen03mpharm@gmail.com
Abstract: Pulsatile drug delivery systems (PDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of disease, resulting in improved patient compliance. Inorder to emulate innate circadian rhythms, a reasonable and generally accepted rationale is a delivery system capable of releasing drugs in pulsatile fashion rather than continuous delivery at predetermined times. PDDS are promising in diseases like asthma, peptic ulcer, arthritis, cardiovascular diseases, attention deficit syndrome in children, hypercholesterolemia. PDDS can be classified into time controlled systems and stimuli controlled systems. This article includes advantages, drawbacks, methodologies, their applications in different pathological conditions.
Keywords: PDDS-Pulsatile drug delivery systems; CR-controlled release; SR-sustained release Back to TOC