Greener Synthesis of Pharmacologically Important Thiosemicarbazides
Arikatla V. Rao*, Arshi Naqvi, Mohd. Shahnawaaz, Daya S. Seth and Peter E. JosephSchool of Chemical Sciences, Chemistry Department, St. John's College, Agra - 282 002 India.
Corresponding Author E-mail: rao_arikatla@yahoo.co.in
Abstract: The synthesis of thiosemicarbazides has been the area of extensive research since decades especially while investigating compounds to be potential pharmacological candidates. In this paper, we propose the synthesis of title compounds by the condensation of o-toluidine and p-toluidine malonamic acid hydrazides with substituted phenyl isothiocyanates under microwave irradiation. The synthesized compounds were subjected to antibacterial screenings.
Keywords: Synthesis; thiosemicarbazides; microwave irradiation; antibacterial screenings Back to TOC