Pathogens Causing Urinary Tract Infection In Children and Their In Vitro Susceptibility to Antimicrobial Agents- A Hospital Based Study
Balaji Chinnasami*, Subha Sundaramoorthy , Kanimozhi Sadasivam and Sekar PasupathySRM Medical College, Hospital and RC, Potheri, Kattankulathur, India. Corresponding Author Email : balajictriumphants@gmail.com
Abstract: To identify common microbes causing urinary tract infection in pediatric population and their resistance pattern to commonly used antibiotics in a south Indian hospital. We retrospectively collected urine culture and sensitivity data of children admitted with suspected urinary tract infection from January 2015 to December 2015. Antimicrobial susceptibility testing was performed by antibiotic disc diffusion method and ESBL production confirmed by Double disk synergy test. About 130 were culture positive with E.coli being the predominant microbe grown (40.8%) and ESBL production was high to the tune of 83% in them. Most Gram negative bacteria were sensitive to aminoglycosides and carbapenams and Gram positive bacteria were susceptible to Vancomycin and Linezolid. ESBL mpositiveE.coli was resistant to many drugs including Penicillins, Cephalosporins and Quinolones. Nitrofurantoin elicited good invitro response to ESBL positive E.coli, Enterococcus and Coagulase Negative Staphylococcus. Our study shows that E.coli is the most common cause of urinary tract infection and since 80% are ESBL producers they are multidrug resistant. Oral Nitrofurantoin is a good choice for uncomplicated urinary tract infection. Parenteral aminoglycosides, Piperacillin/Tazobactum, Cefoperazone/Sulbactum can be recommended for complicated UTI reserving carbapenams for those cases who don’t respond to initial theraphy.
Keywords: Antibiotic resistance; ESBL; E.coli; Klebsiella; Proteus; nitrofurantoin Back to TOC