The Effect of Ájuga Turkestánica on the Rat Aortic Smooth Muscle Ion Channels
Omonturdiev Sirojiddin Zoirovich1*
, Abdullaev Izzatullo Ziyoyiddin ugli1, Inomjonov Dolimjon Raxmatillayevich2, Maxmudov Lazizbek Umarjonovich1 Zaripova Mehrangiz Ravshanovna1, Gayibova Sabina Narimanovna1.2, Gayibov Ulugbek Gapparjanovich1,2and Aripov Takhir Fatikhovich1,21A. S. Sadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Republic Uzbekistan
2Namangan state University Uzbekistan
Corresponding Author E-mail: siroj.2012@mail.ru
Abstract: According to the literature, Ájuga turkestánica extract has an effective impact on diseases of the cardiovascular system. Aortic smooth muscle ion transport systems play an important role in the development of these diseases1. This study investigated the effects of Ájuga turkestánica extract on ion transport systems in rat aortic smooth muscle preparations under isometric conditions in vitro, and it was found that this extract exerts a strong dose-dependent relaxant effect on the contraction induced by KCl (50 mM) From the obtained results, the effect of this extract on potential-dependent Ca2+ channels was estimated, and in order to confirm the assumption, it was compared with verapamil, a specific blocker of this channel, and the effect of Ájuga turkestánica extract on potential-dependent Ca2+ channels was determined. In the course of the studies, it was assumed that the investigated extract affects not only the potential-dependent Ca2+ channels, but also the receptor-dependent Ca2+ channels, the Ca2+ transport system in the sarcoplasmic reticulum, and the endothelium-dependent relaxation mechanisms. According to the results of the study, it was found that Ájuga turkestánica extract has an effective effect on these ion transport systems (the results obtained are described in detail in the article below).
Keywords: Ájuga turkestánica, Ca+2 -ATPase; IP3R, Phenylephrine; Phentolamine; receptor-dependent (TRP) channels; Voltage-gated Ca+ (VGCC) channels Back to TOC