Antimicrobial and Antioxidant Potential of Zanthoxylum armatum from Uttarakhand locations

Kunal Sharma¹, Amit Gupta^2*, Simran Srivastava¹ and Arsh Singh¹

¹Department of Microbiology, Graphic Era Deemed to be University, Dehradun, Uttarakhand India.

²Department of Zoology, University of Jammu, Baba Saheb Ambedkar Road, Tawi, Jammu, Jammu, India.

Corresponding Author E-mail:amit.gupta@jammuuniversity.ac.in

Abstract: In this study, we prepared three extracts (methanolic, ethyl acetate, and n-hexane) of Zanthoxylum armatum from respective regions of Uttarakhand (Bageshwar, Pithoragarh, and Champawat) for determining the antimicrobial activity of fruits and seed samples using the disc diffusion method. These samples were tested in vitro for their ability to inhibit the growth of three different bacterial strains: Pseudomonas aeruginosa, Staphylococcus aureus, and E. coli, and the zone of inhibition was calculated in mm (millimeters). Against the three test pathogens, however, the fruit extracts demonstrated more potent antibacterial activity, but the antibacterial activity of seed extracts was less evident. Staphylococcus aureus was shown to be more susceptible to each of the extracts than other strains. This plant has the potential to treat a wide range of bacterial conditions, including skin infections, urinary tract infections, dental problems, diarrhoea, and dysentery. Similarly, Zanthoxylum armatum fruit and seed extracts were tested for their antioxidant capacity using 2,2′-diphenyl picrylhydrazyl (DPPH) radical scavengers. These studies revealed that the methanolic fruit and seed extract of Zanthoxylum armatum from Bageshwar showed higher antioxidant and antimicrobial effects as compared to the control. Similar effects were obtained from ethyl acetate and n-hexane extracts, but these had a lower effect than the methanolic extract. In short, Zanthoxylum armatum fruits and seeds have shown exceptional antibacterial properties against several pathogenic microorganisms that cause a number of disorders and have also shown antioxidant properties.

Keywords: Antioxidant; Antimicrobial; Fruit; Seed; Zanthoxylum armatum

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