Prophylactic Effects of Coriander Aqueous Extract on Carbendazim -Induced Renal Toxicity in Male Rats
Somaya Y. Shalaby1, Mohamed A. Akela2
, Mustafa Karhib3, Youssef Hussein4, Mohamed Rabea1 and Ehab Tousson5*1Department of Zoology, Faculty of Science, Menoufia University, Egypt
2Department of Biology, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
3Department of Medical Laboratory Techniques, Al-Mustaqbal University College, 51001 Hillah, Babylon, Iraq
4Departmentof Anatomy, Histology and Emberology, Faculty of Medicine, Mutah University, Al-Karak, Jordan
5Department of Zoology, Faculty of Science, Tanta University, Egypt.
Corresponding Author E-mail: ehabtousson@science.tanta.edu.eg
Abstract: A broad spectrum carbamate fungicide called carbendazim (Carb) that is very crucial for preventing plant diseases. and is one of the most pervasive environmental pollutants with serious implications for both human and animal health. In the current study, the role of Coriandrum sativum seeds extract (CSE) on carbendazim induced rats renal toxicity. Carb induced significant elevation in serum creatinine, urea, potassium, kidney malondialdehyde (MDA), nitric oxide (NO), renal injury, PCNA and significant depletion in serum sodium, calcium, renal glutathione (GSH). Treatments of Carb with CSE (CSE+Carb and/or Carb+CSE) improved these parameters and reduced renal toxicity with best results for Carb+CSE than CSE+Carb. Serum phosphorus revealed no significant changes between different groups. The above findings support the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.
Keywords: Antioxidant; Carbendazim; Coriandrum sativum; Kidney Back to TOC