South African Medicinal Plants Used in the Treatment of Human Bacterial Infections: An updated Review
Rose Awah Bih
, Maropeng Charles Monyama and Sogolo Lucky Lebelo*Department of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, Private Bag X06, Florida, South Africa.
Corresponding Author e-mail: lebelol@unisa.ac.za
Abstract: Traditional medicine based on the use of medicinal plants plays an important role in the preservation of health and well-being of many people globally. Today herbal medicine application is progressively finding more significance especially with the acknowledgement of the challenges of antibiotic resistance. The aim of this review was to collect literature based on the traditional application of South African medicinal plant species used in South Africa to prevent and treat various pathogenic bacterial infections. The search was carried out using key electronic scientific databases including PubMed, Google Scholar, SpringerLink, ProQuest, Science Direct, Elsevier, BioMed Central. Other sources of literature included scientific articles, book chapters, dissertations, theses and websites. It was found that Bacillus spp., Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were the most frequently investigated bacterial pathogens which have developed resistance to most of the available standard antibiotics. Organic and aqueous extracts of many South African plants including Acacia karroo, Psidium guajava, Punica granatum, Eucomis autumnalis, Vernonia amygdalina and Cyathula uncinulata have demonstrated potent antibacterial efficacy against the aforementioned pathogens. This review exemplifies that South African medicinal plants have the potential to be considered as new leads for the development of antibacterial agents against resistant pathogens.
Keywords: Antibiotic resistance, Antimicrobials; Human bacterial infections; Medicinal plants; South Africa Back to TOC