Assessment of Liver Enzymes Level in the Serum of Tuberculosis Patientsduring Directly Observed Short Term Chemotherapy (DOTS)
S. C. Narwadiya1, U. L. Dhumne2, P. M. Tumane1 and V. G. Meshram31P.G. Department of Microbiology, R.T.M Nagpur University Nagpur (India).
²National Institute of Miners’ Health, JNARDDC Campus Opp wadi Police Station Wadi, Nagpur (India).
3Sindhu Mahavidyalaya,Panchpaoli,Nagpur (India).
Corresponding Author E-mail:snarwadiya@gmail.com
Abstract: Increase of liver enzymes e.g. LDH and SGPT are common in a tuberculosis regimen. Patients taking anti - TB drugs develop severe hepatitis that may progress to liver failure and death if drugs not stooped promptly (Timberel JA, 1985). Dots chemotherapy in India, treatment of category is divided into 3 types- Category I, II and III. Hepato-toxicity in TB therapy has been well documented but the present study had objectives to assess the liver enzymes according to category of treatment. A total 90 patients were taken in different category of treatment from dot center and analyze SGOT, SGPT and alkaline phosphatase level with respect to detail data was recorded for each and every patient. Study found that significant abnormal rise of liver enzymes in category of treatment II and the values came to near normal in category of treatment III. Due to different drug doses in different category. Study results comparatively related with some other study.
Keywords: Liver Enzymes; TB regimen; Assessment Back to TOC