Anti-Inflammatory Activity of Phytoconstituents of Ginseng Plant- Insilico Approach
Anit Treesa Joy1
, Harish. M2* and Rishad K. S11UniBiosys Biotech Research Labs, Sahaan Arcade, Cochin University Road (CUSAT Jn.), South Kalamassery, Cochin, Kerala India.
2SCMS School of Technology and Management, Biotechnology Division -SIBB R and D, S. Kalamassery, Kochi, Kerala, India
Corresponding Author E-mail: harishmadhav20@gmail.com
Abstract: Ginseng is a plant’s root of the Panax family that is characterized by the presence of ginsenosides. It is used as a traditional medicine for many years in East Asian regions generally as an adaptogenic medicine to make the body resistant to homeostasis and other adverse environmental factors. Inflammation and lipid signaling are intermixed modulators of homeostasis and immunity. Cyclooxygenase is a key enzyme in lipid signalling. The present study focused on the anti-inflammatory analysis of phytoconstituents of the ginseng plant against COX1 and COX2 genes. In this study we approached the study of the interaction of phytoconstituents of ginseng plant with COX-1 and COX-2 using an insilico approach. It is done in 2 main stages: docking between COX1 and COX2 with phytoconstituents of ginseng plant and the ADMET analysis. . The drug-likeness of phytoconstituents were predicted and the ADMET properties. Molecular docking studies were done using the Autodock server and MyPresto program to explore the binding pattern with COX-1 and COX-2. The result showed that phytoconstituents gallic acid and myricetin have high anti-inflammatory action due to the electrostatic force of attraction of COX1 and COX2. Quercetin, and apigenin due to high binding affinity due to the attraction of COX2, epicatechin, and chlorogenic acid on COX1. The phytoconstituents gallic acid, myricetin, apigenin, chlorogenic acid, epicatechin and quercetin can potentially be used as anti-inflammatory agents.
Keywords: Anti-Inflammatory Drugs; ADMET Analysis; Cyclooxygenases; Ginseng; Molecular Docking Back to TOC