Embryo Quality and Intracytoplasmic Sperm Injection (ICSI) Outcome in Iraqi Women with Polycystic Ovary Syndrome (PCOS): A Cohort Prospective Study
Muhjah Falah Hassan1*
, Hind Abdul-Kadim2, Ban Jaber Edan3, Sulagna Dutta4, Pallav Sengupta5*1Department of Anatomy, Histology and Embryology, College of Medicine, University of Kerbala, Kerbala, Iraq
2Department of Uro-surgery and Infertility, College of Medicine, University of Kufa, Kufa, Iraq
3Depatment of Physiology and Medical Physics, College of Medicine, University of Babylon, Babylon, Iraq
4School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Tamil Nadu, India
5Physiology, Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, UAE
Corresponding Author E-mail: allav_cu@yahoo.com
Abstract: Background: Polycystic ovary syndrome (PCOS) is a major cause of ovulatory dysfunctions among reproductive-aged women. PCOS impairs folliculogenesis leading to suboptimal oocyte maturation, impaired embryonic development and pregnancy failure. Intracytoplasmic sperm injection (ICSI) is a popular option for PCOS patients to attain pregnancy. However, there is no specific determinant to ascertain successful pregnancy outcome in PCOS women undergoing ICSI. Objectives: The purpose of this study was to determine the influence of PCOS on embryo quality and subsequent pregnancy rate in Iraqi women who had undergone ICSI. Methods and materials: Over the course of three months, one hundred and three infertile couples who were referred to Al-Sadr Medical City, Kufa, Iraq between October 2017 and June 2018 were enrolled in this study. The couples were divided into two groups: those with PCOS, and those who did not have PCOS. The amounts of hormones were determined. The evaluation of embryo attributes with grading, as well as the determination of the fertilization rate, cleavage rate, and pregnancy rate, were carried out. Results: The difference in fertility and cleavage rates between the PCOS (P=0.40) and non-PCOS (P=0.59) groups was not statistically significant. When comparing the two groups, the mean number of good quality embryos in the PCOS group was higher (P=0.07), whereas the pregnancy rate in the former was considerably lower (P=0.02) than in the latter. Conclusion: According to our findings, PCOS had no negative impact on the quality of the embryos produced by Iraqi women who underwent ICSI treatment. Because PCOS is a complicated disorder characterized by a variety of endogenous physiological variables that may either directly or indirectly interfere with conception, the low likelihood of pregnancy in these patients suggests that good embryo quality is not the only predictor of successful pregnancy.
Keywords: Embryo Quality; Fertilization Rate; Hyperandrogenemia; ICSI Outcome; PCOS; Pregnancy Outcome Back to TOC