Fabrication and Preliminary Assessment of Neem Fruit Mucilage as Mucoadhesive Abetting Assets with Methpol-934P for Acyclovir Delivery from Mucoadhesive Microcapsules
Gorantla Naresh Babu 1, 3
, Menaka Muthukarupan1, Hindustan Abdul Ahad2*, Veerabomma Sreedhar31Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.
2Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu-515721, Andhra Pradesh, India.
3Department of Industrial Pharmacy, Balaji College of Pharmacy, Ananthapuramu-515721, Andhra Pradesh, India.
Corresponding Author E-mail: andulhindustan@gmail.com
Abstract:
In this study, we investigated the mucoadhesive properties of neem fruit mucilage by incorporating it into mucoadhesive microcapsules with Acyclovir (ACR). Methpol-934P and Neem fruit mucilage (NFM) was used to construct 12 different mucoadhesive microcapsules. We assessed FTIR and DSC capabilities for compatibility with ACR and NFM. ACR mucoadhesive microcapsules (ANMM) were characterized for mucoadhesion and ACR release Physico-chemical characteristics. CR was found to be compatible with NFM in the research. The entrapment increased as the levels of NFM in the formulations increased, and mucoadhesion time was longer in formulations with higher levels of NFM. As levels of NFM increase in formulations, the release of drugs is slightly reduced. NFM may be responsible for this due to its release retarding properties. An additive of neem fruit mucilage allowed for the retention of ACR after ingestion when a mucoadhesive polymer (methpol 934P) was used.
Keywords: Acyclovir; anti-viral; Mucoadhesive; Microcapsules; Neem Back to TOC