Therapeutic Effects of Ipomoea batatas L. Extract-Containing Capsule and Simvastatin Combination versus Simvastatin in Dyslipidemic Patients
Anak Agung Ngurah Subawa1*, I Made Jawi2, I Wayan Putu Sutirta-Yasa1, I Wayan Sumardika2, Agung Nova Mahendra21 Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar, Bali, Indonesia.
2 Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia.
Corresponding Author E-mail: ngurah_subawa@unud.ac.id
Abstract: Purple sweet potato extract (PSPE) have been shown to exhibit antidyslipidemic effect, but the clinical effects of PSPE and statin combination has not been investigated. This study was aimed to reveal the effect of PSPE and statin combination on lipid profile, malondialdehyde (MDA) and superoxide dismutase (SOD) level in mild and moderate dyslipidemia cases. The study design was a limited clinical trial with a randomized pre and posttest control group design. Subjects were divided into simvastatin (control) group and simvastatin + PSPE capsules group (10 individuals per group). Both groups received simvastatin 20 mg daily (4 weeks), with the administration of PSPE capsules for the second group 400 mg/day, BID, 4 weeks). The aforementioned variables were subsequently analyzed using paired t-test and t-test, when appropriate. Better lipid profile improvements, lower MDA levels, and higher SOD level (p<0.05) were revealed in patients treated with simvastatin + PSPE compared to simvastatin alone. It can be inferred that combination of PSPE and simvastatin exhibits a clinically better effect as antidyslipidemic agent and antioxidant in dyslipidemic patients than simvastatin alone.
Keywords: Dyslipidemia; Lipid Profile; Oxidative Stress; Purple Sweet Potato Capsules; Simvastatin Back to TOC