Analgesic and Anti-Inflammatory Effects of 1-(4'-Dimethylaminophenyl)-6, 7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride

Khilola A. Rakhmanova¹ , Sherzod N. Zhurakulov², Firuza M. Tursunkhodjayeva¹, Azizbek A. Azamatov¹, Dilfuza M. Saidkhodjayeva¹ and Inoyat Z. Jumayev^2,3*

¹Institute of Chemistry of Plant Substances named after Academician S.Yu. Yunusov of the Academy of Sciences   of the Republic of Uzbekistan, Laboratory of Pharmacology and Toxicology, Tashkent, Uzbekistan.

²Institute of Chemistry of Plant Substances named after academician S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan, Laboratory of Chemistry of Alkaloids, Tashkent, Uzbekistan.

³Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, Uzbekistan.

Corresponding Author E-mail: inoyat8585@mail.ru

Abstract: It is known that natural isoquinoline alkaloids are widely used in pharmacology and have a variety of biological activities¹. At the same time, synthetic analogs of isoquinoline alkaloids are of great interest, among which compounds have been identified that are promising agents that modulate the activity of the dopamine and serotonergic systems^2,3, showing cardiprotective⁴ effect, antiproliferative⁵ and analgesic⁶ activity. Currently, in practical medicine, aspirin and anlagen are widely used as non-narcotic analgesics⁷. However, the low intensity of the analgesic effect, the lack of an analgesic effect in certain types of pain (thermal, mechanical, and other acute pain) and the large number of side effects caused by long-term use limits the scope of their application. The properties of 1-(4’-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) have not been previously described in the scientific literature. The analgesic and anti-inflammatory activity of 1-(4'-dimethylaminophenyl)-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) was studied under conditions of thermal (hot plate test) and chemical (vinegar writhing test) irritation, anti-inflammatory activity - on the model of acute inflammatory arthritis. As a result of the studies, it was found that the compound 1-(4'-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline in various doses has an analgesic and anti-inflammatory effect. 1-(4'-Dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) showed a pronounced anti-inflammatory effect at a dose of 0.5 mg/kg, 3.3 times greater than the effect of diclofenac sodium. It has been shown that 1-(4’-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) has a pronounced analgesic and anti-inflammatory activity and can be used in medical practice as a non-narcotic analgesic.

Keywords: Acute Toxicity; Analgesic and Anti-Inflammatory Activity; Acetylsalicylic Acid; Diclofenac Sodium; Tetrahydroisoquinoline Hydrochloride; metamizole sodium

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