Diastereo selective Synthesis of Phosphonate Ester through the Reaction Between Activated Acetylenic Ester and Heterocyclic NH Compounds with Biological Activity in the Presence of Triphenylphosphite.
Malek Taher Maghsoodlou*, Noroullah Hazeri, Sayyed Mostafa Habibi Khorassani, Forough Jalili Milani, Mohammad Amin Kazemian and Mahdi ShahrakiDepartment of Chemistry, The University of Sistan and Balouchestan, Zahedan (Iran).
Corresponding Author E-mail:smhabibius@ yahoo.com
Abstract: The reaction between dimethyl acetylenedicarboxylate and biological active heterocyclic NH compounds such as 3-methylpyrazole and 3,6-diboromocarbazole in the presence of triphenylphosphite at room temperature led to phosphonate ester 4a-b. The configuration of compounds 4a-b (2S*,3R*)-were determined on the basis of coupling constants emerged from the Karplus equation.
Keywords: Diastereo selectivity; Heterocyclic NH compounds; biological activity; Activated acetylenic ester Back to TOC